Diamicron MR 60mg is an extended-release formulation of gliclazide, a second-generation sulfonylurea medication. This once-daily treatment offers sustained blood glucose control for patients with type 2 diabetes mellitus, enhancing convenience and potentially improving medication adherence.
Uses
Diamicron MR 60mg is primarily used for:
- Treatment of type 2 diabetes mellitus in adults
- Management of blood glucose levels when diet, exercise, and weight reduction alone are insufficient
- Combination therapy with other antidiabetic medications like metformin or insulin
Benefits
- Provides 24-hour glucose control with once-daily dosing
- Reduces HbA1c levels effectively
- Lowers risk of diabetes complications
- Maintains pancreatic beta-cell function
- Reduces cardiovascular risk in diabetic patients
- Offers convenient modified-release formulation
- Minimizes blood sugar fluctuations
- Compatible with other diabetes medications
- Helps prevent diabetic complications
How It Works
Diamicron MR stimulates insulin release from pancreatic beta cells by binding to sulfonylurea receptors. The modified-release formulation provides gradual drug release over 24 hours, maintaining steady blood glucose control. It also improves insulin sensitivity and reduces hepatic glucose production.
Dosage
| Patient Status | Initial Dosage | Maximum Dosage |
|---|---|---|
| Treatment-naive | 30mg once daily | 120mg once daily |
| Switching from standard Gliclazide | Equivalent dose | 120mg once daily |
Take Diamicron MR with breakfast. Swallow tablets whole without crushing or chewing to maintain modified-release properties.
Duration of Action
Diamicron MR begins working within 2-3 hours after administration. Peak effects occur at 6-12 hours with sustained glucose control for 24 hours. The modified-release formulation ensures consistent blood sugar management throughout the day and night.
Side Effects
Most common side effects include hypoglycemia, particularly if meals are skipped. Other effects may include weight gain, nausea, or skin reactions. Rare but serious reactions include severe hypoglycemia, blood disorders, or liver dysfunction. Most patients tolerate the medication well.
Warning
Risk of severe hypoglycemia, especially in elderly patients, those with irregular eating habits, or kidney/liver impairment. Monitor blood glucose regularly. Diamicron MR is contraindicated in Type 1 diabetes, diabetic ketoacidosis, and severe kidney or liver disease. Discontinue before surgery or serious illness.
Pregnancy and Breastfeeding
Diamicron MR is contraindicated during pregnancy. Insulin is preferred for glucose control in pregnant diabetic women. The medication may pass into breast milk, so breastfeeding is not recommended. Women of childbearing age should use effective contraception during treatment.
Interaction
- Enhanced hypoglycemic effects with ACE inhibitors and beta-blockers
- Reduced effectiveness with corticosteroids and thiazide diuretics
- Increased risk of hypoglycemia with alcohol consumption
- May interact with warfarin affecting anticoagulation
- Possible altered effects with certain antibiotics and antifungals
Precaution
Monitor blood glucose regularly, especially during illness, stress, or changes in routine. Use cautiously in elderly patients and those with kidney or liver impairment. Maintain regular meal times and avoid alcohol excess. Carry glucose tablets for hypoglycemia treatment.
Important Information
Diamicron MR requires lifestyle modifications including proper diet and regular exercise for optimal effectiveness. Regular monitoring of HbA1c, kidney function, and liver enzymes is necessary. Store below 30°C in original packaging. Inform all healthcare providers about this medication before procedures or starting new treatments.
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