Orelox Tablet 200mg contains cefpodoxime, a third-generation cephalosporin antibiotic. This broad-spectrum medication effectively treats various bacterial infections, offering a convenient twice-daily dosing regimen for improved patient compliance.
Uses
Orelox Tablet 200mg is primarily used to treat:
- Upper and lower respiratory tract infections
- Pneumonia
- Typhoid fever
- Urinary tract infections
- Skin and soft tissue infections
- Pharyngitis and tonsillitis
- Acute otitis media
- Uncomplicated gonorrhea
Benefits
- Broad-spectrum activity against gram-positive and gram-negative bacteria
- Excellent oral bioavailability and tissue penetration
- Effective against penicillin-resistant strains
- Well-tolerated with minimal gastrointestinal side effects
- Convenient twice-daily dosing regimen
- Rapid onset of antibacterial action
- Good safety profile in most patients
- Suitable for outpatient treatment of serious infections
- Effective alternative to injectable antibiotics
How It Works
Orelox works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins. This action disrupts the formation of peptidoglycan, an essential component of bacterial cell walls, leading to bacterial cell death. Its beta-lactamase stability makes it effective against resistant organisms.
Dosage
| Infection Type | Adult Dosage | Treatment Duration |
|---|---|---|
| Respiratory Tract | 200mg twice daily | 7-14 days |
| Urinary Tract | 100-200mg twice daily | 3-7 days |
| Skin/Soft Tissue | 200mg twice daily | 7-10 days |
Take Orelox with food to enhance absorption. Complete the full course even if symptoms improve early.
Duration of Action
Orelox begins working within hours of administration, with peak blood levels reached 2-3 hours after oral intake. The antibacterial effect is maintained for 12 hours, supporting twice-daily dosing. Clinical improvement typically begins within 48-72 hours of starting treatment.
Side Effects
Most patients tolerate Orelox well. Common side effects include mild diarrhea, nausea, and abdominal discomfort. Some patients experience headache, dizziness, or skin rash. Rare but serious effects include severe diarrhea due to C. difficile infection and allergic reactions.
Warning
Do not use Orelox if allergic to cephalosporins or penicillins. Complete the full prescribed course to prevent antibiotic resistance. Severe diarrhea during or after treatment may indicate C. difficile-associated colitis requiring immediate medical attention. Prolonged use may result in superinfection with resistant organisms.
Pregnancy and Breastfeeding
Orelox is generally considered safe during pregnancy when bacterial infection poses greater risk than medication. It passes into breast milk in small amounts but is usually compatible with breastfeeding. Consult healthcare provider to weigh benefits versus potential risks.
Interaction
- May reduce effectiveness of oral contraceptives
- Possible increased bleeding risk with warfarin
- Antacids may reduce absorption if taken simultaneously
- May cause false-positive results in some urine glucose tests
- Probenecid may increase Orelox blood levels
Precaution
Use cautiously in patients with kidney impairment, requiring dose adjustment. Monitor for signs of allergic reactions, especially in first-time users. Patients with history of gastrointestinal disease need careful monitoring for antibiotic-associated colitis. Avoid alcohol during treatment to prevent potential interactions.
Important Information
Orelox is effective only against bacterial infections, not viral infections like colds or flu. Skipping doses or not completing the full course may decrease effectiveness and increase antibiotic resistance. Store at room temperature away from moisture and heat. Report any severe diarrhea, persistent abdominal pain, or allergic symptoms immediately to your healthcare provider.
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