Oxispa Suspension Dry Syrup 125/5ml

Oxispa Suspension Dry Syrup is an oral antibiotic medication designed to treat a wide range of bacterial infections in both adults and children. This dry syrup formulation contains cefuroxime, a second-generation cephalosporin antibiotic, which is highly effective against various gram-positive and gram-negative bacteria.

Uses

Oxispa Suspension Dry Syrup is indicated for the treatment of various bacterial infections, including:

• Respiratory tract infections (e.g., bronchitis, pneumonia, tonsillitis)
• Urinary tract infections (e.g., cystitis, pyelonephritis)
• Skin and soft tissue infections (e.g., cellulitis, impetigo)
• Ear, nose, and throat infections (e.g., otitis media, sinusitis)
• Bone and joint infections (e.g., osteomyelitis)
• Meningitis (caused by susceptible bacteria)

This broad-spectrum antibiotic can be used to combat infections caused by bacteria such as Streptococcus, Staphylococcus, Haemophilus influenzae, Moraxella catarrhalis, and certain strains of Escherichia coli and Klebsiella.

NOTE: The usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever, is penicillin given by the intramuscular route.

Benefits

• Broad-spectrum activity against gram-positive and gram-negative bacteria
• Convenient oral administration in dry syrup form
• Proven clinical efficacy for various bacterial infections
• Suitable for both outpatient and inpatient treatment
• Effective against resistant strains of common pathogens
• Appropriate for pediatric and adult patients
• Twice-daily dosing for improved compliance
• Stable gastric acid resistance

How It Works

Cefuroxime, the active ingredient in Oxispa Suspension Dry Syrup, belongs to the cephalosporin class of antibiotics. It works by inhibiting the synthesis of the bacterial cell wall, which is essential for bacterial survival and growth. Cefuroxime binds to and inactivates specific enzymes called penicillin-binding proteins (PBPs), which are involved in cell wall formation. This disruption in cell wall synthesis ultimately leads to bacterial cell destruction and infection eradication.

Duration of Action

Oxispa Suspension maintains therapeutic blood levels for approximately 12 hours after administration, with peak plasma concentrations reached within 2-3 hours. The antibiotic remains active in the body with an elimination half-life of 1-2 hours in patients with normal renal function.

Dosage

Indication	Patient Group	Recommended Dosage
Acute tonsillitis, pharyngitis, sinusitis	Children ≥2 years	15 mg/kg twice daily (max 250 mg twice daily)
Otitis media or severe infections	Children ≥2 years	15 mg/kg twice daily (max 250 mg twice daily)
Cystitis	Adults and children	15 mg/kg twice daily (max 250 mg twice daily)
Pyelonephritis	Adults and children	15 mg/kg twice daily (max 250 mg twice daily) for 10-14 days
Uncomplicated skin/soft tissue infections	Adults and children	15 mg/kg twice daily (max 250 mg twice daily)
Lyme disease	Adults and children	15 mg/kg twice daily (max 250 mg twice daily) for 14 days (range 10-21 days)

Warnings

Oxispa Suspension Dry Syrup should be used with caution in individuals with known allergies to cephalosporin antibiotics or any ingredients in the formulation. It should also be used cautiously in patients with impaired renal function, as dose adjustments may be necessary. The usual drug of choice in the treatment and prevention of streptococcal infections, including the prophylaxis of rheumatic fever, is penicillin given by the intramuscular route.

Side Effects

Common side effects may include gastrointestinal disturbances (diarrhea, nausea, vomiting), rash or skin reactions, headache, dizziness, and vaginal yeast infection. Serious but rare side effects may include allergic reactions (anaphylaxis), Clostridium difficile-associated diarrhea, blood disorders (neutropenia, thrombocytopenia), and kidney or liver dysfunction.

Pregnancy and Breastfeeding

Oxispa Suspension should be used during pregnancy only when clearly needed and the benefits outweigh potential risks. Cefuroxime passes into breast milk in small amounts. Nursing mothers should consult their healthcare provider before using this medication.

Interactions

• Antacids and H2-blockers (reduced absorption)
• Probenecid (increased cefuroxime levels)
• Oral contraceptives (possible reduced effectiveness)
• Anticoagulants (possible enhanced effect)
• Nephrotoxic drugs (increased risk of kidney toxicity)
• Bacteriostatic antibiotics (possible antagonistic effect)

Precautions

Complete the full course of treatment even if symptoms improve before finishing. Keep well hydrated while taking this medication. Reconstitute the dry syrup according to instructions and store properly after reconstitution. Monitor for signs of allergic reactions or superinfection. Not suitable for children under 3 months of age.

Important Information

Oxispa Suspension Dry Syrup is a prescription medication and should only be used under the guidance of a qualified healthcare professional. Patients should provide their complete medical history, including any allergies, current medications, and underlying conditions, to ensure safe and effective use of the antibiotic.