Primpex DS (Co-trimoxazole 960mg) x100

Primpex DS contains co-trimoxazole 960mg, combining sulfamethoxazole (800mg) and trimethoprim (160mg). This dual-action antibiotic treats various bacterial infections by preventing bacterial growth and reproduction.

Uses

Primpex DS treats urinary tract infections, respiratory tract infections including bronchitis and pneumonia, ear infections, intestinal infections, and skin infections. It’s also prescribed for preventing and treating Pneumocystis jirovecii pneumonia in immunocompromised patients and for prophylaxis against infections in specific situations.

Benefits

• Treats multiple bacterial infections with dual-mechanism action
• Effective against broad spectrum of pathogens
• Convenient twice-daily dosing schedule
• Available in tablet form for easy administration
• Well-established safety and efficacy profile
• Provides both therapeutic and prophylactic benefits

How It Works

Primpex DS works synergistically as trimethoprim inhibits dihydrofolate reductase while sulfamethoxazole blocks para-aminobenzoic acid utilization. This prevents bacteria from producing essential nucleic acids and proteins needed for survival.

Duration of Action

Effects begin within 1-2 hours with therapeutic levels maintained for 12 hours. Full antibacterial effect requires 48-72 hours. Treatment courses typically range from 5-14 days depending on infection type and severity.

Dosage

Side Effects

Common effects include nausea, vomiting, loss of appetite, and skin rash. Less common: headache, dizziness, and photosensitivity. Rare but serious: severe skin reactions, blood disorders, and allergic reactions. Contact doctor if severe symptoms occur.

Warning

Discontinue if severe skin reactions, breathing difficulties, or unusual bleeding occur. Not recommended with severe liver/kidney disease, blood disorders, or sulfonamide allergy. Maintain adequate fluid intake during treatment.

Pregnancy and Breastfeeding

Not recommended during pregnancy, especially first and third trimesters. Avoid during breastfeeding as active components pass into breast milk. Consult healthcare provider for alternatives if pregnant or breastfeeding.

Interactions

• May increase effects of warfarin and anticoagulants
• Can elevate blood levels of phenytoin
• May interfere with methotrexate clearance
• Can increase potassium with ACE inhibitors
• May reduce oral contraceptive effectiveness

Precaution

Take with full glass of water and stay hydrated. Complete full course even if symptoms improve. Avoid prolonged sun exposure. Monitor for superinfection signs. Periodic blood tests may be needed during long treatment.

Important Information

Only use for bacterial infections, not viral illnesses. Misuse may cause resistance. Take at evenly spaced intervals. Store at room temperature away from moisture. Keep out of reach of children. Do not use expired medication.