Shal’Artem Tablet 20/120mg (Anti-malaria) x12

Shal’Artem Tablet 20/120mg is a fixed-dose combination antimalarial medication containing artemether and lumefantrine. This artemisinin-based combination therapy (ACT) effectively treats acute, uncomplicated malaria caused by Plasmodium falciparum in pediatric patients.

Uses

Shal’Artem Tablet 20/120mg treats acute uncomplicated malaria caused by Plasmodium falciparum parasites. It is effective against multidrug-resistant strains and can be used in areas where chloroquine resistance is prevalent.

Benefits

• Rapid parasite clearance
• Effective against resistant malaria strains
• Fixed-dose combination improves compliance
• Pediatric-appropriate formulation
• Reduces risk of severe malaria complications
• High cure rates with proper administration
• Lower relapse rates compared to monotherapy
• World Health Organization recommended treatment

How It Works

Shal’Artem Tablet works through dual mechanisms of action. Artemether rapidly reduces parasite load by targeting the parasite’s food vacuole. Lumefantrine has a longer half-life and eliminates remaining parasites, preventing recrudescence and reducing the risk of resistance development.

Duration of Action

Artemether acts rapidly with effects within hours, while lumefantrine provides extended antimalarial activity for 4-7 days after treatment completion. The combination ensures complete parasite clearance and prevents recurrence.

Dosage

Warnings

Do not use in patients with severe malaria requiring intravenous treatment. Avoid in patients with known hypersensitivity to artemether or lumefantrine. Not recommended for prophylaxis. Seek immediate medical attention if symptoms worsen or do not improve after treatment.

Side Effects

Common side effects may include headache, dizziness, loss of appetite, nausea, vomiting, abdominal pain, palpitations, joint and muscle pain, fatigue, and sleep disturbances. Most side effects are mild and resolve without intervention.

Pregnancy and Breastfeeding

Safety in pregnancy not fully established but benefits may outweigh risks in malaria treatment. Limited data suggests it is compatible with breastfeeding. Consult healthcare provider before administration to pregnant or breastfeeding patients.

Interactions

• QT-prolonging medications (increased cardiac risk)
• CYP3A4 inhibitors (increased drug levels)
• CYP3A4 inducers (decreased effectiveness)
• Antiretroviral medications (potential interactions)
• Hormonal contraceptives (possible reduced effectiveness)
• Grapefruit juice (increased drug concentration)

Precautions

Administer with food or milk to enhance absorption. All six doses must be completed for effective treatment. Repeat dose if vomiting occurs within 1 hour of administration. Monitor closely for signs of treatment failure. Ensure accurate weight-based dosing for children.

Important Information

Shal’Artem Tablet should be taken with high-fat meals or drinks like milk to maximize absorption. Follow-up within 1-2 weeks after treatment is recommended to ensure complete cure. Treatment should begin as soon as possible after diagnosis. Keep medication out of reach of children not under treatment.