Clexane Injection 4000IU is a sophisticated low molecular weight heparin (LMWH) containing enoxaparin sodium. This advanced anticoagulant provides reliable prevention and treatment of thromboembolic disorders with improved safety and convenience compared to traditional heparin.
Uses
- Prevention of deep vein thrombosis (DVT)
- Treatment of acute DVT and pulmonary embolism
- Prevention of clotting during hemodialysis
- Management of acute coronary syndromes
- Prevention of ischemic complications
- Post-surgical thrombosis prophylaxis
- Treatment of unstable angina
Benefits
- Offers predictable anticoagulation response
- Reduces risk of thrombocytopenia
- Provides convenient once/twice daily dosing
- Eliminates routine coagulation monitoring
- Enables outpatient management
- Shows high bioavailability
- Demonstrates consistent efficacy
- Maintains favorable safety profile
How It Works
Clexane enhances antithrombin III activity, specifically targeting Factor Xa in the coagulation cascade. This selective inhibition prevents prothrombin conversion to thrombin, effectively blocking clot formation while maintaining a controlled anticoagulant effect.
Dosage and Duration
| Indication | Dose | Treatment Duration |
|---|---|---|
| DVT Prophylaxis | 4000IU once daily | As prescribed |
| Surgical Prophylaxis | 4000IU once daily | 7-10 days |
| Active DVT Treatment | Weight-based twice daily | 5-10 days |
| Hemodialysis | Based on circuit | During dialysis |
Side Effects
Most common effects include injection site reactions and minor bleeding. Monitor for unusual bleeding, bruising, or signs of thrombocytopenia.
Warning
Use cautiously in patients with bleeding disorders, severe hypertension, or history of heparin-induced thrombocytopenia. Contraindicated with active major bleeding.
Pregnancy and Breastfeeding
Clexane Injection is generally considered safe during pregnancy and breastfeeding under medical supervision. Regular monitoring recommended.
Interactions
- Increased bleeding risk with anticoagulants
- Potential interactions with antiplatelet drugs
- Risk enhancement with NSAIDs
- Careful monitoring with systemic salicylates
- Caution with vitamin K antagonists
Precautions
Administer via subcutaneous injection only. Rotate injection sites. Monitor platelet counts periodically. Avoid intramuscular injections while on therapy.
Important Information
Store Clexane Injection 4000IU between 15-25°C in original packaging, protected from light. Check solution clarity before use. Use proper injection technique with clean anterolateral abdominal sites. Monitor platelet counts and watch for unusual bleeding. Carry medical alert identification. Don’t stop treatment without consulting healthcare provider. Keep emergency contacts accessible and attend all follow-up appointments.
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