Amatem Softgel Capsule 20/120 x24

Amatem Softgel combines Artemether (80mg) and Lumefantrine (480mg) in a convenient softgel form. This artemisinin-based combination therapy (ACT) offers potent and rapid action against malaria, particularly Plasmodium falciparum infections. The softgel formulation enhances absorption and patient compliance.

Uses

Amatem Softgel is primarily indicated for:

• Treatment of acute, uncomplicated malaria caused by Plasmodium falciparum
• Management of mixed malarial infections including P. falciparum

Benefits

• Rapid and effective clearance of malaria parasites
• Softgel formulation for improved absorption and ease of administration
• Effective against drug-resistant strains of P. falciparum
• Reduces risk of recrudescence and treatment failure
• Combination therapy helps prevent development of resistance
• Suitable for both adults and children (based on weight)

How It Works

Artemether rapidly reduces parasite load by interfering with protein synthesis. Lumefantrine eliminates remaining parasites by disrupting their mitochondrial function. This dual-action approach ensures comprehensive parasite clearance and prevents recurrence.

Dosage

Typical adult dosage (>35kg):

• 4 softgels twice daily for 3 days (total of 24 softgels)
• First two doses given 8 hours apart, then 12 hours apart for the remaining doses

Dosage may vary based on weight. Always follow your healthcare provider’s instructions.

Side Effects

Common side effects may include:

• Headache and dizziness
• Nausea, vomiting, and abdominal pain
• Fatigue
• Loss of appetite
• Palpitations
• Muscle and joint pain

Seek medical attention if side effects are severe or persistent.

Warning

• Not recommended in first trimester of pregnancy unless no alternatives are available
• Use with caution in patients with liver or kidney impairment
• Not for malaria prophylaxis
• Avoid in patients with known QT interval prolongation

Interaction

Amatem Softgel may interact with:

• CYP3A4 inhibitors or inducers
• QT-prolonging drugs
• Antiretroviral medications
• Hormonal contraceptives (may reduce efficacy)

Inform your healthcare provider of all medications you’re taking.

Important Information

Complete the full course of treatment even if symptoms improve. Take with fatty food or milk to enhance absorption. If vomiting occurs within 1 hour of dosing, repeat the dose. This medication doesn’t prevent malaria transmission; continue using protective measures against mosquito bites. Seek medical attention if fever persists or returns within 4 weeks after treatment.