Dogrel-75 Tablet is a prescription medication containing Clopidogrel, an antiplatelet agent used to reduce the risk of atherothrombotic events such as heart attacks, strokes, and peripheral arterial disease. By inhibiting platelet aggregation, Clopidogrel helps prevent the formation of blood clots in arteries, thereby lowering the risk of serious cardiovascular complications.
Uses
Dogrel-75 Tablet is used for:
- Prevention of atherothrombotic events in patients with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease
- Prevention of atherothrombotic and thromboembolic events in patients with atrial fibrillation who are unable to take oral anticoagulation therapy
Benefits
- Reduces the risk of heart attacks, strokes, and peripheral arterial disease by preventing the formation of blood clots in arteries
- Provides effective long-term protection against atherothrombotic events
- Suitable for patients who have experienced a recent heart attack, stroke, or have established peripheral arterial disease
- Offers an alternative to oral anticoagulation therapy for patients with atrial fibrillation who are unable to take such medications
Mechanism of Action
Clopidogrel, the active ingredient in Dogrel-75 Tablet, works by inhibiting the binding of adenosine diphosphate (ADP) to its platelet receptor, thus preventing ADP-mediated platelet activation and aggregation. By reducing platelet aggregation, Clopidogrel decreases the risk of blood clot formation in arteries, which can lead to serious cardiovascular events such as heart attacks and strokes.
Duration of Action
The antiplatelet effects begin within 2 hours of taking the first dose. Maximum platelet inhibition occurs after 4-7 days of regular dosing. The effects can last for 5-7 days after discontinuation due to the irreversible nature of platelet inhibition.
Dosage
Patient Category | Daily Dose | Treatment Duration & Schedule |
---|---|---|
Standard Treatment | 75mg | One tablet daily, long-term |
Post-Acute Event | 75mg | One tablet daily with initial loading dose |
Prevention | 75mg | One tablet daily as prescribed |
Side Effects
Common side effects include bleeding tendencies such as easy bruising and prolonged bleeding time. Patients may experience gastrointestinal disturbances, skin reactions, and headaches. Most side effects are mild and manageable.
Warning
Increased risk of bleeding is significant, especially during surgery or trauma. Discontinue treatment 5-7 days before planned surgery. Monitor for signs of unusual bleeding or bruising. Requires immediate medical attention for severe bleeding events.
Pregnancy and Breastfeeding
Use during pregnancy should be based on careful assessment of benefits versus risks. Not recommended during breastfeeding due to potential risks to the infant. Consult healthcare provider for guidance.
Interactions
- Increases bleeding risk with anticoagulants
- May interact with NSAIDs and aspirin
- Reduced effectiveness with certain proton pump inhibitors
- Potential interactions with other antiplatelet drugs
- May be affected by certain antidepressants
Precautions
Monitor for signs of bleeding. Regular blood count checks may be needed. Avoid activities with high risk of injury. Report any unusual bleeding or bruising to healthcare provider immediately.
Important Information
Take consistently at the same time each day. Do not stop medication without consulting healthcare provider. Carry medical identification indicating use of antiplatelet medication. Store at room temperature away from moisture and heat.
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