Grutha Fort 80/480mg Soft Gelatin x6

Grutha Fort 80/480mg is a fixed-dose combination antimalarial medication containing Artemether (80mg) and Lumefantrine (480mg). This artemisinin-based combination therapy (ACT) effectively treats uncomplicated malaria, including drug-resistant strains of Plasmodium falciparum.

Uses

Grutha Fort 80/480mg treats acute uncomplicated Plasmodium falciparum malaria, including chloroquine-resistant strains. It’s also used for malaria chemoprophylaxis in high-risk endemic areas where resistance to other antimalarials is documented.

Benefits

• Rapidly clears Plasmodium falciparum malaria infection
• Effective against multi-drug resistant malaria strains
• Prevents complications associated with severe malaria
• Combination therapy reduces risk of parasite resistance
• Well-tolerated with a convenient dosing regimen
• Provides both rapid action and extended protection
• Recommended by WHO for first-line malaria treatment
• High cure rates in various endemic regions

How It Works

Artemether provides rapid parasite clearance by generating free radicals that damage parasite membranes. Lumefantrine, with its longer half-life, prevents recrudescence and eliminates remaining parasites. This dual-action ensures both immediate relief and complete parasite clearance.

Dosage

Take with food or milk to enhance absorption. Complete the full course as prescribed.

Duration of Action

Grutha Fort begins working within hours of the first dose. Artemether provides rapid parasite clearance within 24-48 hours, while Lumefantrine continues working for 4-5 days after the last dose, preventing recurrence. Most patients experience fever resolution within 24-36 hours of starting treatment.

Side Effects

Common side effects include headache, dizziness, nausea, vomiting, abdominal pain, loss of appetite, and palpitations. Most reactions are mild to moderate and resolve without intervention. Sleep disturbances and fatigue may occur but typically subside after completing treatment.

Warning

Do not use if allergic to artemether, lumefantrine, or related compounds. Use with caution in patients with severe malaria or hepatic/renal impairment. Not recommended for severe cardiac disease due to potential QT interval prolongation. Seek immediate medical attention for severe vomiting, difficulty breathing, or irregular heartbeat.

Pregnancy and Breastfeeding

Avoid Grutha Fort during the first trimester of pregnancy unless no alternatives exist and benefits outweigh risks. Generally considered safe in second and third trimesters. Limited data exists on breastfeeding, though benefits typically outweigh risks in malaria-endemic regions. Consult healthcare provider before use.

Interaction

• May interact with medications that prolong QT interval
• Reduced effectiveness when taken with CYP3A4 enzyme inducers
• Potential increased side effects with CYP3A4 inhibitors
• Possible interaction with certain antiretroviral drugs
• May affect hormonal contraceptive effectiveness
• Grapefruit juice may increase drug concentration levels

Precaution

Take with fatty food or milk to enhance absorption. Use with caution in patients with cardiac conditions, electrolyte abnormalities, or seizure disorders. Monitor patients with liver or kidney dysfunction. Avoid in those with history of allergic reactions to artemisinin derivatives. Complete the full treatment course even if symptoms resolve quickly.

Important Information

Grutha Fort does not prevent malaria transmission to others. Continue protective measures against mosquito bites. If vomiting occurs within one hour of taking a dose, repeat the dose. Seek medical attention if fever persists after completing the full course. Store below 30°C in original packaging, protected from light and moisture.