P-Alaxin TS (Dihydroartemisin+Piperaquine)

P-Alaxin TS Tablet is an advanced antimalarial medication that combines two potent active ingredients: dihydroartemisinin and piperaquine. This dual-action formulation provides effective treatment for acute uncomplicated malaria, particularly in regions with drug-resistant Plasmodium strains.

Uses

P-Alaxin TS is primarily used for treating acute, uncomplicated malaria caused by P. falciparum. It’s also effective in managing malaria in areas with multi-drug resistant strains and treating mixed malarial infections.

Benefits

• Highly effective against drug-resistant malaria strains
• Rapid parasite clearance
• Prolonged protective effect against reinfection
• Convenient once-daily dosing regimen
• Well-tolerated with a favorable safety profile
• Suitable for both adults and children

How It Works

Dihydroartemisinin rapidly reduces parasite load by interfering with the parasite’s ability to detoxify heme. Piperaquine, with its longer half-life, eliminates residual parasites and provides extended protection against reinfection.

Duration of Action

The rapid-acting dihydroartemisinin component begins working within hours of administration. The long-acting piperaquine component provides protection against reinfection for up to 4-5 weeks after treatment.

Dosage

Take P-Alaxin TS with water on an empty stomach, at least 3 hours before or after a meal. Always follow your healthcare provider’s dosing instructions.

Warnings

P-Alaxin TS should not be used for malaria prevention. It’s not recommended for patients with severe malaria or certain heart conditions. Use caution in patients with liver or kidney impairment. This medication may prolong the QT interval, potentially causing abnormal heart rhythms.

Side Effects

Common side effects may include headache, dizziness, fatigue, loss of appetite, nausea, abdominal pain, and mild diarrhea. These are usually mild and transient. Serious side effects are rare but can include severe allergic reactions, abnormal heart rhythms, or liver problems. Contact your healthcare provider if you experience severe or persistent side effects.

Pregnancy and Breastfeeding

P-Alaxin TS should be used during pregnancy only when clearly needed and when the benefits outweigh potential risks. Pregnant women in their first trimester should use the medication only if no alternatives are available. Consult a healthcare provider regarding breastfeeding while taking this medication.

Interactions

• QT-prolonging medications (increased risk of cardiac arrhythmias)
• Certain antidepressants and antipsychotics
• Some antibiotics (macrolides, fluoroquinolones)
• CYP3A4 inhibitors or inducers
• Antihistamines
• Antifungal medications
• Grapefruit juice (may increase drug levels)

Precautions

Complete the full course of treatment even if symptoms improve. If vomiting occurs within 30 minutes of dosing, repeat the dose. Avoid grapefruit juice during treatment. Patients with cardiac conditions should be monitored. Use under medical supervision in children under 25kg.

Important Information

Take P-Alaxin TS on an empty stomach to ensure optimal absorption. Seek medical attention if fever persists or returns within 28 days after treatment. Use effective birth control during and for at least 3 months after treatment if of childbearing age. This medication does not prevent transmission of malaria to others.