Panfor SR-500mg Tablet (Metformin) x100

Panfor SR-500mg is an oral antidiabetic medication containing metformin hydrochloride in a sustained-release formulation. It’s used to manage type 2 diabetes mellitus. This formulation provides gradual drug release throughout the day, allowing for convenient once-daily dosing while maintaining effective glycemic control.

Uses

Panfor SR-500mg is primarily used for management of type 2 diabetes mellitus, as an adjunct to diet and exercise in improving glycemic control. It may be used in combination with other antidiabetic agents. There is potential off-label use in polycystic ovary syndrome (PCOS).

Benefits

• Effective control of blood glucose levels
• May aid in weight loss or weight maintenance
• Reduces risk of diabetes-related complications
• Once-daily dosing improves adherence
• Does not cause hypoglycemia when used alone
• May have cardiovascular benefits in diabetic patients

How It Works

Metformin reduces hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity. This results in lowered blood glucose levels without causing hypoglycemia.

Duration of Action

The sustained-release formulation of Panfor SR-500mg provides a controlled release of metformin over 24 hours, allowing for once-daily dosing. This maintains stable drug levels throughout the day for consistent glycemic control.

Dosage

Warnings

Not recommended for patients with severe kidney dysfunction. Avoid alcohol consumption. Temporarily discontinue before radiologic studies using iodinated contrast or surgical procedures. Risk of lactic acidosis in certain conditions like severe infection, liver disease, or heart failure.

Side Effects

Common side effects may include gastrointestinal issues like nausea, diarrhea, and abdominal discomfort. These often subside over time. Less common effects can include taste disturbance and vitamin B12 deficiency with long-term use. Rare but serious side effects may include lactic acidosis. Seek immediate medical attention if you experience severe muscle pain, trouble breathing, or unusual tiredness.

Pregnancy and Breastfeeding

Consult your healthcare provider before using Panfor SR-500mg during pregnancy or breastfeeding. Alternative diabetes management may be recommended during pregnancy. Metformin is excreted in breast milk in small amounts.

Interactions

• Cimetidine (may increase metformin levels)
• Furosemide (may affect metformin levels)
• Nifedipine (may increase metformin absorption)
• Cationic drugs (potential interaction)
• Alcohol (increases risk of lactic acidosis)
• Iodinated contrast agents (increased risk of renal failure)
• Other hypoglycemic medications (enhanced glucose-lowering effect)

Precautions

Take Panfor SR-500mg with your evening meal to minimize gastrointestinal side effects. Do not crush or chew the tablet; swallow whole. Regular monitoring of blood glucose and HbA1c is essential. Inform your doctor if you experience persistent nausea, vomiting, or abdominal pain.

Important Information

Maintain a healthy diet and exercise regimen as part of your diabetes management plan. If you miss a dose, take it as soon as you remember unless it’s close to your next scheduled dose. Regular kidney function tests are recommended during treatment. Vitamin B12 levels should be monitored during long-term therapy, especially in patients with anemia or peripheral neuropathy.