Prexidin Injection is a powerful third-generation cephalosporin antibiotic containing ceftazidime. This injectable medication is specifically designed for treating severe bacterial infections. It offers broad-spectrum antimicrobial coverage, particularly effective against gram-negative bacteria, including Pseudomonas aeruginosa.
Uses
Prexidin Injection treats serious bacterial infections including lower respiratory tract infections, pneumonia, urinary tract infections, septicemia, bone and joint infections, meningitis, and severe skin/soft tissue infections. It’s particularly valuable in hospital settings for treating resistant bacterial strains.
Benefits
- Provides rapid action against severe infections
- Effective against resistant bacterial strains
- Broad-spectrum antimicrobial coverage
- High penetration into body tissues
- Treats multiple types of infections
- Suitable for hospital-acquired infections
- Compatible with many other medications
- Excellent safety profile when properly administered
How It Works
Prexidin Injection works by interfering with bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting the bacterial cell wall formation process, which leads to cell lysis and bacterial death. Its unique structure provides enhanced stability against many β-lactamases.
Dosage
| Type of Infection | Dosage | Duration and Frequency |
|---|---|---|
| Severe Infections | 2g | Every 8 hours for 7-14 days |
| Moderate Infections | 1g | Every 8-12 hours for 7-10 days |
| Critical Care | 2g | Every 6-8 hours for 14-21 days |
Duration of Action
Prexidin reaches peak plasma concentrations within 1 hour after administration. The antibiotic maintains therapeutic levels in the blood for 8-12 hours. Complete treatment duration varies based on infection severity and response.
Side Effects
Common side effects include injection site reactions, gastrointestinal disturbances, and mild allergic reactions. Serious side effects may include severe allergic reactions, Clostridium difficile-associated diarrhea, and changes in blood cell counts.
Warning
Immediate medical attention is required if signs of severe allergic reaction occur, including rash, itching, swelling, severe dizziness, or difficulty breathing. Monitor for superinfection during prolonged use.
Pregnancy and Breastfeeding
Category B medication for pregnancy. Use during pregnancy only when clearly needed. Ceftazidime passes into breast milk; consult healthcare provider before use while breastfeeding.
Interactions
- Beta-lactam antibiotics
- Aminoglycosides (potential synergistic effect)
- Probenecid increases ceftazidime levels
- Oral contraceptives may be less effective
- Loop diuretics may increase nephrotoxicity risk
Precautions
Requires renal dose adjustment in patients with kidney impairment. Regular monitoring of kidney function and blood counts may be necessary. Always use aseptic technique for preparation and administration. Maintain adequate hydration during treatment.
Important Information
Prexidin must be administered by qualified healthcare professionals. Complete the full course of treatment even if symptoms improve. Regular monitoring of infection markers and organ function is essential. Store unreconstituted vials properly and use reconstituted solution within recommended time frame.
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