Zodipine-30 SR is a sustained-release formulation containing nifedipine 30mg, a potent calcium channel blocker designed for once-daily dosing. This specialized formulation provides consistent blood pressure control and angina prevention through controlled medication release over 24 hours.
Uses
- Management of mild to moderate hypertension
- Prevention and treatment of chronic stable angina
- Treatment of vasospastic (Prinzmetal’s) angina
- Management of Raynaud’s phenomenon
- Reduction of cardiovascular risk in select patients
- Control of hypertensive emergencies (specialist use)
- Treatment of certain types of peripheral vascular disease
Benefits
- Delivers effective 24-hour blood pressure control
- Reduces frequency and severity of angina attacks
- Improves exercise tolerance and capacity
- Enhances peripheral circulation in Raynaud’s phenomenon
- Provides convenient once-daily dosing
- Minimizes blood pressure fluctuations
- Offers smooth onset of action
- Shows excellent tolerability profile
How It Works
Zodipine-30 SR works by blocking calcium channels in vascular smooth muscle and cardiac cells. This prevents calcium influx, causing blood vessel dilation (vasodilation) and reduced peripheral resistance, ultimately lowering blood pressure and improving oxygen supply to the heart.
Dosage and Duration
| Condition | Dosage | Treatment Duration |
|---|---|---|
| Hypertension | 30-90mg once daily | Ongoing/Long-term |
| Chronic Angina | 30-60mg once daily | As needed/Long-term |
| Raynaud’s | 30mg once daily | Seasonal/As needed |
Side Effects
Common effects include headache, flushing, ankle swelling, and dizziness. These typically diminish after continued use. Report persistent or severe side effects to your healthcare provider.
Warning
Contraindicated in severe hypotension, heart failure, or aortic stenosis. Avoid abrupt discontinuation. May cause initial hypotension upon starting therapy. Not suitable for acute angina attacks.
Pregnancy and Breastfeeding
Use during pregnancy only when benefits clearly outweigh risks. Alternative medications preferred during breastfeeding. Consult healthcare provider before use.
Interactions
- Enhanced effects with antihypertensives
- Decreased efficacy with NSAIDs
- Significant interaction with grapefruit products
- Potential interactions with certain antibiotics
- Effects altered by CYP3A4 inhibitors/inducers
Precautions
Take with food to reduce stomach irritation. Do not crush or chew tablets. Monitor blood pressure regularly. Avoid alcohol. Rise slowly from sitting or lying position to prevent dizziness.
Important Information
Take Zodipine-30 SR at the same time daily with food. Swallow tablet whole. Continue medication even when feeling well. Monitor blood pressure regularly. Report unusual side effects promptly. Avoid grapefruit products. Carry medical identification indicating calcium channel blocker use.
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