Primpex Tablet (Co-Trimoxazole) x100

Primpex Tablet contains Co-Trimoxazole an antibiotic, a combination of Sulfamethoxazole 400mg and Trimethoprim 80mg that works against a wide spectrum of bacteria. The dual-action formulation targets different stages of bacterial metabolism for enhanced antimicrobial effectiveness.

Uses

Primpex Tablet treats urinary tract infections, respiratory tract infections, ear infections, gastrointestinal infections, skin and soft tissue infections, and Pneumocystis pneumonia. It’s also used prophylactically in immunocompromised patients and for traveler’s diarrhea prevention.

Benefits

• Broad-spectrum antibacterial activity
• Dual-mechanism antimicrobial action
• Effective against resistant strains
• Convenient twice-daily dosing
• Cost-effective treatment option
• Rapid symptom relief
• High tissue penetration
• Available in tablet form for easy administration

How It Works

Primpex Tablet contains two active ingredients that work synergistically. Sulfamethoxazole inhibits bacterial folic acid synthesis while Trimethoprim blocks the enzyme dihydrofolate reductase. This sequential blockade in folate pathway prevents bacterial DNA synthesis and ultimately leads to bacterial cell death.

Duration of Action

Effects begin within 1-4 hours after administration. The half-life of Trimethoprim is approximately 8-10 hours while Sulfamethoxazole’s half-life is 9-12 hours, enabling twice-daily dosing in most cases.

Dosage

Warnings

Discontinue immediately if skin rash, sore throat, fever, or pallor occurs as these may indicate serious adverse reactions. Not recommended for pregnant women near term, nursing mothers, infants under 2 months, or patients with severe liver or kidney impairment.

Side Effects

Common side effects include nausea, vomiting, loss of appetite, and mild skin rashes. Serious side effects may include severe skin reactions, blood disorders, liver problems, kidney problems, and photosensitivity reactions.

Pregnancy and Breastfeeding

Not recommended during pregnancy, especially near term. Contraindicated during breastfeeding as both components pass into breast milk and may cause kernicterus in jaundiced infants or G6PD deficiency.

Interactions

• Warfarin (increased anticoagulant effect)
• Phenytoin (increased blood levels)
• Methotrexate (increased toxicity risk)
• ACE inhibitors (increased hyperkalemia risk)
• Oral hypoglycemics (enhanced effect)
• Cyclosporine (reduced clearance)
• Potassium supplements (hyperkalemia risk)

Precautions

Complete the full prescribed course even if symptoms improve. Take with plenty of fluids to prevent crystalluria. Monitor blood counts during prolonged therapy. Avoid sun exposure or use sun protection. Elderly patients may require dosage adjustments and closer monitoring.

Important Information

Primpex Tablet should be taken at regular intervals to maintain antibiotic blood levels. If you miss a dose, take it as soon as you remember unless it’s nearly time for your next dose. Report any unusual symptoms promptly to your healthcare provider.