Triaxin-S Injection 1.5g I.M/IV

Triaxin-S Injection is a potent combination antibiotic containing Ceftriaxone Sodium and Sulbactam Sodium. This dual-action formulation is designed for intramuscular (I.M) or intravenous (I.V) administration, providing broad-spectrum antimicrobial coverage. It’s particularly effective against a wide range of bacterial infections, including those resistant to other antibiotics.

Uses

Triaxin-S is used to treat various severe bacterial infections, including:

• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Bone and joint infections
• Meningitis
• Septicemia
• Surgical prophylaxis

Benefits

• Broad-spectrum antibacterial activity
• Effective against many antibiotic-resistant strains
• Combination therapy reduces the risk of resistance development
• Flexible administration route (I.M or I.V)
• Extended half-life allows for less frequent dosing

How it Works

Ceftriaxone, a third-generation cephalosporin, inhibits bacterial cell wall synthesis. Sulbactam, a beta-lactamase inhibitor, protects ceftriaxone from degradation by certain bacterial enzymes, enhancing its effectiveness against resistant strains.

Dosage

Duration of Action

Triaxin-S begins working within 30 minutes of administration. Peak plasma levels occur in 2-3 hours with therapeutic concentrations maintained for 12-24 hours. Treatment duration typically ranges from 5-14 days depending on infection type and severity.

Side Effects

Common side effects include injection site reactions, mild gastrointestinal disturbances, headache, and occasional skin rash. Serious but rare effects may include severe allergic reactions, blood disorders, or Clostridium difficile-associated diarrhea.

Warning

Use with caution in patients with penicillin or cephalosporin allergy history. Monitor renal and hepatic function during prolonged use. Not recommended for neonates with hyperbilirubinemia. Discontinue if severe hypersensitivity reactions occur.

Pregnancy and Breastfeeding

Use Triaxin-S during pregnancy only when clearly needed. The medication passes into breast milk in small amounts. Consult your healthcare provider about risks and benefits if pregnant or breastfeeding.

Interactions

• May enhance effects of anticoagulants
• Potential increased nephrotoxicity with aminoglycosides
• Possible reduced efficacy with bacteriostatic antibiotics
• May cause false positive results in certain glucose tests
• Avoid calcium-containing products within 48 hours of administration

Precautions

Use cautiously in patients with history of gastrointestinal disease, especially colitis. Adjust dosage in severe renal or hepatic impairment. Monitor for superinfection during prolonged use. Avoid rapid bolus administration in elderly patients.

Important Information

Complete the full prescribed course of Triaxin-S even when symptoms improve. Inform your healthcare provider of all medications you’re taking to prevent interactions. This medication may interfere with certain laboratory tests. Store reconstituted solution according to temperature recommendations.