Pionorm-30 Tablet (Pioglitazone) x30

Pionorm-30 is an oral antidiabetic medication containing pioglitazone, a thiazolidinedione class drug. This insulin sensitizer effectively manages type 2 diabetes by improving insulin sensitivity in target tissues, helping maintain optimal blood glucose levels.

Uses

Pionorm-30 is primarily used to treat type 2 diabetes mellitus, either alone or in combination with other diabetes medications. It’s particularly effective when diet, exercise, and first-line medications haven’t achieved adequate glycemic control.

Benefits

• Improves insulin sensitivity
• Reduces insulin resistance
• Helps maintain stable blood sugar levels
• Lowers glycated hemoglobin (HbA1c)
• May improve lipid profile
• Once-daily convenient dosing
• Can be combined with other diabetes medications
• Helps prevent diabetes complications

How It Works

Pionorm-30 activates PPAR-gamma receptors, enhancing insulin sensitivity in muscle, fat, and liver tissues. This action improves glucose uptake and utilization while reducing glucose production in the liver, leading to better blood sugar control.

Dosage

Duration of Action

Effects begin within 1-2 weeks of starting treatment. Maximum blood glucose-lowering effect typically achieved within 8-12 weeks. The medication provides 24-hour coverage with once-daily dosing.

Side Effects

Common side effects include weight gain, fluid retention, and mild anemia. More serious side effects may include heart failure, bone fractures, and bladder cancer risk. Regular monitoring is essential.

Warning

Seek immediate medical attention if experiencing symptoms of heart failure (shortness of breath, rapid weight gain, edema), liver problems, or vision changes. Not recommended for patients with active bladder cancer or heart failure.

Pregnancy and Breastfeeding

Contraindicated during pregnancy; switch to insulin therapy for diabetes management. Should not be used during breastfeeding due to potential risks to the infant.

Interactions

• Insulin and sulfonylureas
• Oral contraceptives
• Gemfibrozil
• CYP2C8 inhibitors
• NSAIDs may increase fluid retention

Precautions

Regular monitoring of liver function is required. Watch for signs of fluid retention or heart failure. Monitor bone density in at-risk patients. Maintain regular blood glucose testing. Report unusual fatigue or yellowing of skin/eyes immediately.

Important Information

Pionorm-30 should be part of a comprehensive diabetes management program including diet, exercise, and regular blood sugar monitoring. The medication may take several weeks to show full effect. Regular HbA1c testing is essential to monitor long-term control. Take medication at the same time each day. Weight monitoring is important due to potential fluid retention.